The synthesis of 2,4,6-triaryl-1,3,5-triazines using iron-catalyzed cyclization of aldehydes with NH4I as the only nitrogen source is shown to be an easy, atom-efficient process. This method provides symmetrical 2,4,6-trisubstituted and unsymmetrical 1,3,5-triazines with yields ranging from 52% to 85% and operates without difficulty in an environment of air. The current methodology offers a simple and atom-efficient way for making 2,4,6-trisubstituted 1,3,5-triazines that uses an affordable, widely accessible ammonium salt as the only nitrogen source.

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In this communication, condensation from different aromatic, aliphatic and heteroaromatic aldehydes, hydroxyl amine, and sodium azide in toluene reflux was used to produce electronically and structurally distinct tetrazoles with a range of yields 5-94%. Zn(OAc)2•2H2O (10 mol%) was used as a catalyst in the synthesis, which was eco-friendly, readily available, and affordable. The IR, NMR, and mass spectral studies were utilized in order to carry out a comprehensive characterization for all the 5-aryl tetrazole derivatives. This approach contributes to the current chemical synthesis of 5-substituted-1H-tetrazoles in an appealing and convenient manner thanks to its quick reaction times, good to exceptional yields, safe process, and straightforward workup.