This study evaluated the dose-dependent effect of avocado (Persea americana) peel hydroethanolic extract on antioxidant status of heart and kidney tissue homogenates in wistar rats. A total of 60 wistar rats were used and the study period lasted for 42 days. The animals were randomly sampled into six (6) groups; Group i-normal untreated wistar rats, ii-P. americana peel extract (50 mg/kg), iiilead acetate (100 mg/kg), iv-P. americana peel extract (50 mg/kg) + lead acetate (100 mg/kg), v-P. americana peel extract (100 mg/kg) + lead acetate (100 mg/kg) and vi-P. americana peel extract (150 mg/kg) + lead acetate (100 mg/kg). Biomarkers assayed for include antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase; non-enzyme antioxidant reduced glutathione; isoprostanes and malondialdehyde. The extract caused a dose-dependent increase in antioxidant enzymes and non-enzyme markers when administered alone and when combined with Original Research Article