Air quality is a growing environmental concern that has implications for human physical and mental health. While air pollution has been linked to cognitive disease progression and declines in overall health, the impacts of air quality on athletic performance have not been extensively investigated. Much of the previous research focused on endurance sports indicates that air quality negatively impacts athletic performance; however, the effects of air quality on non-endurance elite team performance remains largely unknown. The purpose of this study was to examine the impact of air quality on errors committed by Major League Baseball (MLB) teams, interceptions thrown by quarterbacks in the National Football League (NFL), and overall quarterback performance in the NFL. Linear regression analysis was used to determine the impact of the median air quality index (AQI) of counties with MLB and NFL teams on errors, interceptions, and overall quarterback performance of players on those MLB and NFL teams. AQI was a significant positive predictor of errors and interceptions, indicating increased errors and interceptions with decreased air quality. Similarly, quarterback performance was significantly reduced for quarterbacks from teams in counties with worse air quality. These findings suggest that air quality has a significant impact on performance in the MLB and NFL, indicating impairments in physical and cognitive performance in professional athletes when competing in areas with poorer air quality. Hence, it is likely that air quality impacts athletic performance in numerous sports that have not yet been investigated.