From year to year the number of cases of people with HIV/AIDS has increased. This increase is also experienced in Indonesia, where adolescents infected with HIV/AIDS show a number that tends to rise. It is characterized by a teenager's ignorance about reproductive health and knowledge of his sexual state. So many teenagers are at risk for early marriage problems, pregnancy, sexually transmitted infections, and also HIV/AIDS. To look at the influence of HIV/AIDS education on the knowledge, attitudes, and Practice of Adolescent girls. Use Pre-Experiment with one group pre-test and post-test design. Sampling technique using purposive sampling and obtained the number of 47 students. The research was conducted in Senior High School 12 Makassar in September-October 2021. Data analysis using the McNemar Test. And statistical test results showed there was an influence on the use of HIV/AIDS education using web-based She Smart on knowledge where p-value = 0,000, attitude with a value of p-value = 0.000, and no significant difference in action with p-value = 0.500.  There is an influence on the use of web-based HIV/AIDS education using She Smart on knowledge and attitudes but no significant influence on actions before and after an intervention.

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