The Belt and Road Initiative, formerly known as One Belt One Road or OBOR for short, is a global infrastructure development strategy adopted by the Chinese government in 2013 to invest in nearly 70 countries and international organizations. This initiative aims to achieve the “Chinese Dream”- globalization. The economic status of China is widely flourishing since the introduction of the One Belt One Road initiative among Central Asian-African Countries, particularly in Uzbekistan. Orientation for the five priorities of the initiative is policy coordination, infrastructure connectivity, free trade, financial integration, and soft power bonds. This research demonstrates case reports of bilateral cooperation between China and Uzbekistan, mapping political, financial, economic, and cultural interactions to each of these cooperation priorities. The researchers explored references from scientific peer review articles, e-books, annual and monthly conference reports, available books, and scientific databases and documented valuable data. The researcher evaluated each cooperative agreement and determined the mutual interest and future opportunities for bilateral cooperation between target countries. Base on the findings, it is recommended that China’s political and economic interactions in Uzbekistan need further investigation in the nearest future.