Background: Candidiasis is a fungal disease caused by Candida albicans, a yeast that preferentially affects mucous membranes. These diseases are more and more recurrent because of the generalized decline in immunity and the appearance of resistance to classical antifungal drugs. Therefore, fighting against therapeutic failures becomes necessary. The objective of this study is to contribute to the fight against candidiasis through the research of new antifungal molecules. To do so, the hydroalcoholic extracts of Terminalia catappa, Terminalia glaucescens, Terminalia ivorensis, Terminalia mantaly and Terminalia superba, five plant species used in traditional medicine against dermatoses, were tested on the in vitro growth of resistant strains of Candida albicans. In addition, the polyphenol composition of these plants was carried out in order to evaluate their protective powers. Methods: The antifungal tests were performed by the solid-state dilution method. While the determination of polyphenols was performed by the photometric method. Results: The results showed an inhibition of the growth of germs by four plants except Terminalia catappa. The minimum inhibitory concentrations (MIC) obtained are as follows: MIC (T. ivorensis) =0.25 mg/mL; MIC (T. glaucescens) =0.50 mg/mL; MIC (T. superba) = 4 mg/ML; MIC (T. mantaly) = 2 mg/mL. Conclusion: This study indicates that T. ivorensis is the most active and has the highest content of phenolic compounds. This plant could be a source of effective molecules in the treatment of candidiasis. Keywords: Candida albicans, candidiasis, Terminalia, antifungal, polyphenol,
This survey, which took place in the midst of the Covid 19 global health crisis, was conducted on medicinal plants used in the traditional treatment of the most common viral diseases in Côte d'Ivoire. The aim was to inventory the plant species sold and collect ethnopharmacological data related to these plants. Semi-structured interviews were conducted with herbalists in nine markets in the district of Abidjan. The information collected was processed using SPSS 17.0 computer and statistical software. This study revealed that shingles, yellow fever and chickenpox are the viral diseases for which there are more traditional remedies. A total of 61 species of antiviral medicinal plants distribued in 59 genera and 54 botanical families were identified. Fabaceae (14.75 %), Asteraceae (9.8 %), and Apocynaceae (9.8 %) are the most represented families. Six species are most commonly used in the treatment of viral diseases. They are, in decreasing order of frequency of use: Ocimum gratissimum, Citrus aurantiifolia, Spondias mombin, Allium sativum, Gymnanthemum amygdalinum, Kalanchoe crenata. The leaves are the most used parts, in the form of a decoction (73.84 %). This is consistent with the predominance of the beverage (39.62 %) as a form of use and the oral route of administration (42 %). This study, which allowed the collection of ethnomedicinal data, is positioned as an orientation in the search for effective active ingredients against emerging ET re-emerging viral diseases.
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