Context: ETDE shown good antihypertensive and antioxidant activities in rats made hypertensive. This present study aims to assess its toxicity. Aims: This study was designed to study the toxicity of dichloromethaneethanol extract of Morinda morindoides. Settings and Design: Toxicological activity in vivo. Methods and Material: Alkaloids were characterized from reagents of Bouchardat, flavonoids by reacting the cyanidrine, tannins by the reagent Stiasny, polyphenols by reacting ferric chloride, quinones by the reagent Bornstraëgen, sterols and polyterpenes by the reaction of Libermann and saponins by observing the foam after agitation of the extract. Acute and subacute toxicity were studied using respectively 423 and 407 OECD guidelines for testing of chemicals. Statistical analysis used:The graphical representation of the data was performed using the Graph Pad Prism 5.0. The mean value is accompanied by the standard error of the mean (Mean ± SEM). The difference between the two values is considered significant when P<0.001. Statistical analysis of results was performed using analysis of variance (ANOVA). Results: The phytochemical screening showed the presence in the ETDE of polyphenols, alkaloids, flavonoids, sterols and polyterpenes. The toxicological study shows that ETDE has a LD 50 between 2000 and 5000 mg/kg bw therefore classified in the hazard category 5. The administration of ETDE at repeated dose for 28 days did not significantly affect the weight gain, hematological and biochemical parameters of rats. Conclusion: ETDE toxicity is relatively low with LD 50 between 2000 and 5000 mg/kg bw. It does not cause damage to the heart, liver and kidney. ETDE can be used without risk of intoxication.

Aim: These ethnobotanical investigations within drug sellers of medicinal plants in Côte d'Ivoire (CI) were performed in order to contribute to a better knowledge of plants with antidiabetic effect. They were carried in Adjamé "Quartier rouge" in the district of Abidjan. Methods and Results: The results obtained allowed to inventory 16 species of medicinal plants belonging to 13 families. All of these species are used in the treatment of various pathologies such as diabetes. In order to establish the safety of these plants in the diabetic treatment, acute toxicity tests were performed. To this end, the LD50 was determined in rats. It was determined haematological and biochemical parameters after repeated dosing of 2000 mg/kg of body weight (bw) of aqueous extract of Calotropis procera„leaf, Bauhinia thonningi‟fruit, Fagara zanthoxyloides‟barks and Cassia siberiana‟roots to those rats during 14 days. The aqueous extracts had no effect on most of blood parameters tests. These studies have shown that aqueous extracts of these plants were not toxic in the experimental dose. Conclusion: This study was conducted in the context to perform pharmacological and toxicological experiments for implementation of innovative initiatives in Côte d‟Ivoire. That may lead in the future, to the manufacture of improved traditional drugs (TID).