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This study aimed to investigate the relationship between muscle hardness and muscle tension in terms of length-tension relationship. A frog gastrocnemius muscle sample was horizontally mounted on the base plate inside a chamber and was stretched from 100 to 150% of the pre-length, in 5% increments. After each step of muscle lengthening, electrical field stimulation for induction of tetanus was applied using platinum-plate electrodes positioned on either side of the muscle submerged in Ringer's solution. The measurement of muscle hardness, i.e., applying perpendicular distortion, was performed whilst maintaining the plateau of passive and tetanic tension. The relationship between normalised tension and normalised muscle hardness was evaluated. The length-hardness diagram could be created from the modification with the length-tension diagram. It is noteworthy that muscle hardness was proportional to passive and total tension. Regression analysis revealed a significant correlation between muscle hardness and passive and total tension, with a significant positive slope (passive tension: r = 0.986, P < 0.001; total tension: r = 0.856, P < 0.001). In conclusion, our results suggest that muscle hardness depends on muscle tension in most ranges of muscle length in the length-tension diagram.

The engineering validation and engineering design activity (EVEDA) for the International Fusion Materials Irradiation Facility (IFMIF) is proceeding as one of the ITER broader approach activities. In the concept of the IFMIF, two 40 MeV deuteron beams are injected into a liquid Li stream (Li target) flowing at a velocity of 15 m s −1. The EVEDA Li test loop (ELTL) is aimed at validating the hydraulic stability of the Li target at a velocity up to 20 m s −1 under a vacuum condition of 10 −3 Pa as the most important issue. Construction of the ELTL, which is the largest liquid metal loop possessing 5.0 m 3 Li for the fusion research ever, was completed in the O-arai Research & Development Center in the Japan Atomic Energy Agency on 22 November 2010. This paper presents the design and fabrication technology of a target assembly called integrated target assembly, in which the Li target is produced by a contraction nozzle along a concave channel. There are two concepts regarding the target assembly: the integrated target assembly and the bayonet target assembly. Both target assemblies are outlined in this paper, and then the newly proposed design of the integrated target assembly for the ELTL and its fabrication technology are given. The integrated target assembly was processed by a five-axis milling machine and the processing accuracy was measured by 3D measurement tools. Finally, methods applied for the validation of the stability of the Li target are introduced in this paper.

BackgroundCronkhite-Canada syndrome (CCS) is a rare non-inherited disorder, characterized by gastrointestinal polyposis and ectodermal changes. The pathophysiology remains unclear. Treatment with corticosteroids is considered the mainstay treatment because of its high efficacy. However, some patients have steroid-resistant CCS. The therapeutic strategy for steroid-resistant CCS is not yet established. We report two cases with steroid-resistant CCS that were effectively treated with cyclosporine (CyA). We evaluated the therapeutic strategy for steroid-resistant CCS based on reviews of previous reports.Case presentationOur patients with CCS were first treated with prednisolone. No clinical response was noted, and treatment with CyA was initiated. After beginning CyA treatment, both clinical symptoms and polyposis markedly improved. Up to the present, 55 cases of CCS treated with corticosteroids and their response were reported. Out of the 57 patients, including our 2 cases, 9 (16 %) did not respond clinically to corticosteroids. In 7 of the 9 steroid-resistant cases, the prognosis after corticosteroids treatment was described. In 5 of the 7 steroid-resistant cases, immunosuppressive treatments induced remission. In 4 of these 5 cases, moreover, the key drug of treatments was calcineurin inhibitor.ConclusionsTreatment with calcineurin inhibitor, such as CyA, could be a potential option for steroid-resistant CCS.Electronic supplementary materialThe online version of this article (doi:10.1186/s12876-016-0541-1) contains supplementary material, which is available to authorized users.