Objectives The involvement of pharmacists is very important in achieving the goals of therapeutic management of malaria. This study aimed to analyse the profile of pharmacist interventions (PIs) and to assess their relevance in cases of malaria in children. Methods We conducted a cross-sectional descriptive study in a general hospital in Cote d'Ivoire. The information collected was based on the classification of drug-related problems (DRPs) and PIs of the French Society of Clinical Pharmacy. The score assigned to each PI varied from PI 0 to PI 3 according to its clinical impact. The rating used was as follows: PI 0 (PI without direct clinical impact); PI 1 (PI with significant clinical impact); PI 2 (PI with very significant clinical impact); and PI 3 (PI with vital clinical impact). The relevance of PIs was evaluated by their acceptance rate by physicians and by their clinical impact. Key findings The study included 323 patients. The main DRPs detected were untreated indications (63%) and overdose (26%). The most important PIs concerned propositions of therapeutic choice (90%) (drug addition and treatment discontinuation). Antimalarial drugs were implicated in 14% of PIs. All PIs were accepted by the physicians. PIs were rated by physicians as PI 0 (66%) and as PI 1 (34%). Conclusion Pharmacist interventions for malaria in children were relevant with a high acceptance rate and an appreciable clinical impact.