Background and Aim: Type 2 diabetes mellitus is a metabolic disease characterized by insulin resistance which gives it the place of chronic inflammatory disease. The aim of this study was to show the value of assaying us CRP in Type 2 Diabetics (T2DM) in the prediction of proathherogenic inflammation. Methods: This is a case-control study carried out in 33 T2DM followed in the metabolic diseases service of the University Hospital of Brazzaville (CHUB) between October and December 2020 and 30 controls separated into two subgroups, 15 subjects at risk intermediates and 15 professional athletes. Results: The comparison of the means of the concentrations of the biological parameters between the controls and the diabetic subjects of group I and group II showed a significant difference for CRP-us (p = 0.002), fasting blood glucose (p <0.0001) , the level of HBA1c (p <0.0001). A significant difference for creatinine was observed only for group II and controls. Conclusion: A correlation was obtained between CRP-us and fasting blood sugar, HBA1c, LDL-C and BMI. CRP-us is an excellent marker to predict the onset of vascular disease.