Acute myeloid leukemia (AML) accounts for approximately 15–20% of all childhood leukemia cases. The overall survival of children with acute myeloid leukemia does not exceed 82%, and the 5-year event-free survival rates range from 46% to 69%. Such suboptimal outcomes are the result of numerous mutations and epigenetic changes occurring in this disease that adversely affect the susceptibility to treatment and relapse rate. We describe various molecular-targeted therapies that have been developed in recent years to meet these challenges and were or are currently being studied in clinical trials. First introduced in adult AML, novel forms of treatment are slowly beginning to change the therapeutic approach to pediatric AML. Despite promising results of clinical trials investigating new drugs, further clinical studies involving greater numbers of pediatric patients are still needed to improve the outcomes in childhood AML.

Introduction and purpose of the work: Rheumatic diseases are chronic diseases that cause symptoms in many systems of the human body. Their most common symptoms include pain and symptoms of arthritis, their deformities, fatigue, and malaise. The aim of the article is to present the symptoms and mental disorders occurring in the course of selected rheumatic diseases. State of knowledge: The psychological symptoms are characteristic of systemic lupus erythematosus. Specified is a form of lupus called NSPLE (neuropsychiatric systemic lupus erythematosus), which includes neuropsychiatric symptoms in the course of systemic lupus erythematosus. Psychiatric symptoms are also present in the course of other rheumatic diseases. Neuropsychiatric symptoms may affect up to 80% of patients with primary Sjogren's syndrome, with 50% to 80% ahead of diagnosis. It has been proven that systemic slcerosis causes microvascular damage, which may cause neuropsychiatric symptoms in the form of mood disorders, anxiety and cognitive disorders. In one study, 59% of patients with fibromyalgia experienced mania, which was more than twice as high as in the control group. Summary: In the course of all rheumatic diseases presented by us, there are symptoms and mental disorders. They are often mood, cognitive and sleep disturbances. It should be emphasized that the etiology of psychiatric symptoms is multifactorial.

Introduction: The pathogenesis of inflammatory bowel disease (IBD) is still unknown. It is known to be multi-factorial. The world is seeing an ever increasing number of new cases of these diseases. Ulcerative colitis and Crohn's disease are the main representatives of inflammatory bowel diseases. Aim: The aim of the study was to analyze risk factors for inflammatory bowel diseases. Materials and methods: The results were obtained on the basis of a questionnaire survey. Results: 95 people took part in the survey aged 16 to 72 years old. 35.8% were men and 64.2% were women. 78% lives in cites, only 22% are rural residents.  56.4% of them suffer from ulcerative colitis and 43.6% from Crohn's disease. 40.4% of respondents smoked cigarettes in the past, but currently only 12.6% are still struggling with the addiction. Only 4 people declare brushing their teeth after each meal. 18 people confirm the presence of NCDH in their families, 19 suffer from other autoimmune diseases at the same time. 2 people from among the respondents - also celiac disease. One person had Salmonella and Shigella infection.  Conclusions: Due to the mutual cause-effect relationships between genetic predisposition and the influence of environmental factors, it is currently difficult to state which of the above factors plays a decisive role. Environmental factors that play a role in the etiopathogenesis of IBD include, first and foremost, the intestinal bacterial flora, diet, human environment and smoking. There is a clear tendency for the coexistence of autoimmune diseases in the group of patients with NCJ and a predisposition to the disease in the family. There is also a need to educate patients about the benefits of taking probiotics and taking care of proper eating habits. Key words: inflammatory bowel diseases, risk of developing the disease, irresponsible patient

Introduction and purpose:    The COVID-19 pandemic has significantly affected the health, life and quality of life of many people around the world. It caused huge changes in the daily functioning of entire societies. Pregnant women are a unique group of people who are particularly at risk. They are accompanied by fear for their health, but also fear of the impact of the disease on their offspring. The pandemic has also caused new challenges for mothers-to-be that have not occurred so far. In this paper, we would like to present the current state of knowledge on the impact of SARS-CoV-2 infection on the risk of developing pre-eclampsia.   State of knowledge:   We analyzed studies showing the impact of COVID-19 infection on the health of pregnant women, especially on the risk of developing pre-eclampsia. Data from many studies are contradictory. Some studies do not indicate a significant impact of coronavirus infection on the development of pre-eclampsia. Some of them confirm a higher incidence of pre-eclampsia in pregnant women with confirmed COVID-19 infection.   Conclusions:   Despite the experience gained, there are still many unknowns. Thanks to research, we have more and more knowledge about the course of COVID-19 in pregnant women and its impact on their lives. Many observations are still needed to formulate clear conclusions about the impact of COVID-19 on the risk of developing pre-eclampsia. It is also necessary to continue to educate women, encourage compliance with the recommendations of doctors and the World Health Organization to prevent the spread of coronavirus.

Acne vulgaris is one of the most common chronic skin diseases among people between 15 and 40 years of age.[i] It would seem that it is a typical disease of adolescence. However, it also very often affects adults. One of the most common causes of acne vulgaris in adult women is polycystic ovary syndrome (PCOS). The hyperandrogenism and metabolic disorders present in this syndrome may contribute to the formation of blackheads, pimples, and cysts on the face, chest and back. This article focuses on a review of current acne treatments associated with polycystic ovary syndrome.   [i] Stern RS. Medication and medical service utilization for acne 1995-1998. J Am Acad Dermatol 2000; 43: 1042-1048