In the past decade, asymmetric synthesis of chiral ligands containing quinoline motifs, a family of natural products displaying a broad range of structural diversity and their metal complexes have become the most significant methodology for the generation of enantiomerically pure compounds of biological and pharmaceutical interest. This review provides comprehensive insight on the plethora of nitrogen-based chiral ligands containing quinoline motifs and organocatalysts used in asymmetric synthesis. However, it is circumscribed to the synthesis of quinoline-based chiral ligands and metal complexes, and their applications in asymmetric synthesis as a homogeneous and heterogeneous catalyst.

Based on the literature review, we have found that Isatin-Oxadiazole derivatives are exhibiting different activities like anti-oxidant, antiviral, anti-microbial and anti-convulsant and we synthesized Isatin-Oxadiazole hybrids. Among the series of compounds (E)-5-chloro-3,(2,(5-mercapto-1,3,4-oxadiazol-2yl)hydrazono)-indolin-2-one(IVb), (E)-5-bromo-3,(2,(5-mercapto-1,3,4-oxadiazol-2-yl)hydrazono)indolin-2-one(IVe) showed most significant antioxidant activity.