BACKGROUNDSystemic Lupus Erythematous (SLE) is an autoimmune disorder with a multi-system clinical presentation. Due to its less prevalence, its diagnosis still confuses the health care providers. It occurs most commonly in young women and apart from its clinical presentation, many serological markers and histological findings can aid as important tools in its confirmed diagnosis. Some marked oral manifestations of this systemic disease and immunological presentation of increased antinuclear antibodies, anti-DS-DNA and IgE along with a blood picture of pancytopenia hints a lot more about this rare autoimmune disease. Management of SLE is a complex issue and starts with patient education, counselling and assurance about the relapsing, remission pattern and unpredictable course of the disease. The aim of SLE management is based on prevention; reversal of inflammation, maintaining states of remission and alleviation of symptoms.