Background: Transfusion-related infection is an important mode of human immunodeficiency virus (HIV) transmission. There are very few reports in the literature on transfusion-related HIV from India. Methods: Retrospective study of clinical profile of patients with transfusion related HIV infection presenting to a tertiary care hospital in South India between May 1999 to December 2011. Results: Among the 1332 records of HIV positive patients reviewed, 80 (6 %) had transfusion-related HIV infection; their mean age was 32.2 ± 12.2 years; there were 47 (58.8%) women. Sixty nine patients (86.3%) were infected with HIV-1, while 11 patients (13.8%) were infected with HIV-2 The average number of units of blood transfused was 2.8. The indications for transfusion were perioperative (n=37, 46.3%); haematologic disorders (n=15, 18.8%); trauma (n=9, 11.3%); upper gastrointestinal bleed (n=3, 3.8%); miscellaneous (n=3, 3.8%) and diagnosis not clear at the time of transfusion (n=13, 16.3%). Twenty six of the 64 patients (40.6%) had CD4+ count less than 200 cells/mm

Pyogenic meningitis is one of the most acute dramatic disease which can occur at all ages and is a potentially curable one. 80% of pyogenic meningitis cases occur in children. 1 it is 100% fatal if untreated and survivors are left with major intellectual, psychiatric and neurological handicap. The present study was undertaken in order to find out the age and sex distribution, incidence of presenting features, rapid and confirmatory diagnosis of pyogenic meningitis. We are frequently posed with problems in differentiating between tuberculous meningitis and partially treated pyogenic meningitis, because of the negative results of Gram's staining and culture. 2 The estimation of C-reactive protein in CSF, a rapid and highly sensitive tool, has been used to differentiate them. 3 The specificity of CRP test was found out by estimating CRP in CSF of twenty patients with various neurological disorders other than pyogenic meningitis.