As the surgical techniques for the Fontan operation have changed over the last 40 years, survival has improved. However, development of PLE and arrhythmias and the need for reoperation during long-term follow-up pose significant management challenges.

Background-Approximately 10% of sudden infant death syndrome (SIDS) may stem from potentially lethal cardiac channelopathies, with approximately half of channelopathic SIDS involving the Na V 1.5 cardiac sodium channel. Recently, Na V beta subunits have been implicated in various cardiac arrhythmias. Thus, the four genes encoding Na V beta subunits represent plausible candidate genes for SIDS.

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The coronavirus disease 2019 pandemic has led to a massive activation of clinical research. The methodological strength of these studies is not well characterized but has implications for the quality of evidence produced. We evaluated the characteristics and expected strength of evidence of COVID-19 studies registered on ClinicalTrials.gov.