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Background: Prostatic carcinoma is the second most common cause of cancer deaths in men and the incidence is increasing significantly in recent years, due to early screening measures. A study designed to identify the prostatic lesions spectrum as per histopathological classification. Materials and Methods: 50 prostatic lesion samples collected in 10% formalin were subjected to H and E stain and the mean AgNOR counts were calculated. Results: Out of 50 specimens, 80% were benign and 20% belongs to malignancy. The mean age of patient's benign and malignant lesions is 63.5 ± 9.2 years and 69.5 ± 8.5 years respectively (P=0.09). The most common clinical symptom of benign lesions was frequency in35 patients, followed by hesitancy and nocturia in 33 and 30 patients respectively. Serum PSA values above 10ng/ml were seen in 10 benign cases and 5 malignant cases (P=0.02). Out of 50 cases, 35 were BPH, 5 were non-specific granulomatous prostatitis, 8 prostatic adenocarcinoma, 1 case urothelial carcinoma and 1case with both prostatic adenocarcinoma and urothelial carcinoma were recorded. High grade PIN identified in 9 specimens and low grade PIN identified in 8 specimens. High grade PIN shows association with adenocarcinoma. Basal cell hyperplasia identified in 3 specimens. Tufting Pattern was observed in 2 specimens, flat Pattern observed in 4 specimens, and cribriform pattern observed in 1 specimen out of 9. Majority of patients diagnosed as conventional adenocarcinoma with a score of 9 (3 cases) followed by score of 8 (2 cases). Conclusion: BHP is the most common non neoplastic prostate lesion, and commonly encountered in age group of 60-70 years. In the current scenario, histopathological analysis of prostate specimens plays crucial role in both diagnosis and management.

The prospective study is aimed to study the clinicopathological characteristics of various non infectious papulo -squamous lesions among the skin biopsies. Materials and Methods: Skin biopsies of patients presenting with clinical manifestations of Papulosquamous lesions to the outpatient Department of dermatology. A total of 65 cases were studied. Results: During the study period total number of skin biopsies received was 192, among These, non infectious Papulo -squamous lesions were 65, accounting to 33.85%. In the present study Lichen Planus (64.6 %) was the most common lesion followed by Psoriasis (24.6 %), Pityriasis Rosea (6.2%), and Pityriasis Rubra Pilaris (3.1 %). Conclusion: Papulo -squamous lesions of skin are commonly seen by Dermatologists in their daily practice and because of the considerable overlap in their clinical pattern, presentation and distribution, clinical diagnosis is often difficult. So histopathological study will give a conclusive diagnosis.