No abstract

Synthesized benzimidazole induced Schiff base analogues were characterized by mass, 13C NMR, 1H NMR and UV-visible spectroscopy. To get more information about binding mechanism, molecular docking studies were carried out and the obtained results concluded that the compounds could effectively bind with receptor. in vitro Antibacterial screening was carried out against four strains (S. aureus, B. subtilis, P. aeruginosa and E. coli) and exhibited good antibacterial activity. The gastrointestinal absorption (HIA) and brain penetration (BBB) was evaluated by The BOILED-Egg model, which showed that two compounds anticipated being effectively effluated by the P-glycoprotein from central nervous system after penetration and can accounts for brain access and passive gastrointestinal absorption. Computational screening showed 0.55 bioavailability score for all synthesized compounds.

No abstract

We have developed rapid and efficient method for the synthesis of pharmacologically active N-phenyl acetamide derivatives of indolo [2, 3-b] quinoxaline by using microwave irradiations. Condensation of Substituted phenyl iodoacetamide derivatives with indolo [2, 3-b] quinoxaline under the influence of microwave radiations gave the products. Microwave assisted synthesis not only reduced the reaction time drastically but also gave excellent yields of N-phenyl acetamide derivatives of indolo [2, 3-b] quinoxaline.

No abstract