Introduction: Comprehensive medication management (CMM) is a patient care process provided by clinical pharmacists in primary care settings that ensures optimal use of medications with timely followup. Despite widespread evidence that shows CMM improves clinical and medication-related outcomes, pharmacist CMM services often fail to be adopted into U.S. primary care settings. Objective: This study presents a conceptual framework linking outcomes of pharmacist-delivered CMM services in primary care settings to financial benefits for both primary care practices investing and implementing CMM and health plans providing coverage of CMM services. Methods: A narrative literature review was performed in PubMed and the gray literature to identify financing opportunities that justify the coverage of CMM by third party health plan administrators or the implementation of CMM by primary care practices. Financing elements that could be impacted by pharmacist-led CMM outcomes, namely higher achievement of medication-related quality measures and reduction of total costs of care, were recorded and utilized to develop the conceptual framework. Results: The framework suggests that CMM may provide economic benefits to health plans and care practices by (1) increasing market competitiveness through higher quality ratings, accreditation recognition, lower premiums and plan bids, and increased patient satisfaction; and (2) increasing revenue through quality bonus payments, shared savings agreements, and fee-for-service reimbursement. Conclusions: The alignment of economic benefits that can be realized through CMM advances a strong value proposition for greater adoption of CMM in the United States' primary care system. Future application of this study's conceptual framework could include use as an advocacy tool amongst pharmacy associations or as a tool for individuals seeking buy-in for CMM services.