The risk factors associated with 34 deep infections from a consecutive series of803 total hip replacements have been analysed using standard actuarial methods. The follow-up ranged from 3 to 10 years. Absence of prophylactic antibiotics, complications after operation, discharging wounds, previous operations and remote infection were related to the development of deep periprosthetic infection. An early discharge from the wound with growth of microorganisms , though superficial in appearance, proved to be associated with a high risk of developing late deep infection. The mechanisms associated with deep infection involved multiple interrelated risk factors. Multiple regression analysis PATIENTS AND METHODS The first 803 total hip replacements performed on 695 patients in our clinic between March 1, 1970, and December 31 , 1977, were chosen for this study. The mean age of the patients was 64 years (range 32 to 8 1 years). Most patients were being followed up at regular intervals. A final review was made early in 1981 and

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