Understanding substitution and elimination reactions is a critically important key to comprehending chemical reactions and their mechanisms. Memorizing differences between these reactions is one of the most commonly used strategies to learn this subject. A card game is a helpful supplement to teaching substitution and elimination reactions. A new organic chemistry card game, CHEMCompete, is presented that helps students predict the products of substitution and elimination reactions of alkyl halides and classify the types of these reactions. This game encourages cooperative learning in an enjoyable setting. Significant improvements were observed in both students’ self-rated survey responses and quiz scores evaluating their understanding of this topic. CHEMCompete is an effective study tool for learning substitution and elimination reactions of alkyl halides.