Anemia is a common condition in women of childbearing age which is associated with wide spread hyperplastic processes in the uterus (leiomyomas, etc.) and abnormal and/ or abundant uterine bleeding (AUB). Our study has considered the main causes of bleeding and the therapy aimed on limiting the amount of blood loss, as well as preoperative treatment of iron deficiency in women with uterine leiomyomas, planning for pregnancy.The combination of anemia with other abnormalities in the woman's health status is associated with complications during pregnancy such as premature births, the birth of small children and failure of the formation of neural tube in iron deficiency and hypoxia. During the treatment of iron deficiency anemia (IDA) with saline iron, we noted severity and pain in the stomach in 11.9% of patients, nausea in 13.1%, constipation in 21.4%, and diarrhea in 7.1% of women. Such complications did not occur while treating with ferric iron. The use of drugs Iron III hydroxide polymaltozate in women after the end of lactation resulted in normalization of the blood hemoglobin within 30 days and the number of erythrocytes and of serum ferritin by the 90th day.

Constipation is one of the most common problems. About half of pregnant women experience stool retention, which occurs due to maternal physiological changes in pregnancy: the action of progesterone, uterine growth and other causes, can cause complications of pregnancy, childbirth and the postpartum period and requires treatment. However, this condition is not discussed enough among obstetrician-gynecologists. In the authors’ opinion, the importance of the problem is underestimated. The clinical data provided in the text of the article show that intestinal biocenosis disorder due to chronic colostasis in pregnant women can become a predisposing factor for bacterial vaginosis. In addition, constipation in pregnancy is one of the risk factors that may increase the rate of preterm birth, premature rupture of membranes, birth of small-for-date babies and other complications. For these reasons, the problem demands close attention of the medical community. The article provides basic information about the causes, endocrine, metabolic and other prerequisites for constipation, the features of their manifestations during pregnancy, possible complications, modern pharmacological and non-pharmacological treatments and lifestyle correction capabilities. The authors provided a list of essential drugs to treat constipation, described indications and contraindications for use of such drugs during pregnancy and listed side effects. Sodium picosulfate may be used in the second and third trimesters, which restores the passage of stools in the intestine in a short time and is not contraindicated in a pregnancy. Consideration has been given to the usage of the drug in the practice of obstetrician-gynecologists.

Biological potential of childbearing in the women of late reproductive age is limited by natural impairment and loss of fertility. Despite a considerable progress in clinical application of new diagnostic and reproductive technologies, the problem of infertility remains a most serious challenge. Women’s age is one of the main factors responsible for the outcome of in vitro fertilization. The low effectiveness of in vitro fertilization programs is attributed to discoordination in the hypothalamic-pituitary system, depletion of ovarian resources, and deterioration of quality of reproductive material. Bearing in mind the role of melatonin in synchronizing circadian and seasonal biorhythms and regulating physiological and pathological processes, it is natural to suggest its role in the enhancement of efficiency of in vitro fertilization programs for women of late reproductive age.

Introduction. The problem of iron deficiency anemia by pregnant women remains relevant due to the wide spread of this complication (up to 40%) and requires the search for effective drugs with a minimum number of side effects.Aim. To improve perinatal outcomes in patients with iron deficiency anemia.Materials and methods. A retrospective analysis was done for 2020 of the medical records of patients, including an exchange card and birth histories. The patients were selected by a continuous sampling method. The study was conducted at the clinical base of the Department of Obstetrics and Gynecology with the course of perinatology of the Peoples’ Friendship University of Russia (Head of the Department, Corresponding Member of the Russian Academy of Sciences, Professor V.E. Radzinsky). All the patients (n = 114) were divided into three groups: the first group (n = 54) – a study group, which included pregnant women who had iron deficiency anemia in the II or III trimesters and received antianemic treatment; the second group (n = 30) – pregnant women with iron deficiency anemia (diagnosed in the 2nd trimester) who did not take iron supplements, the third group (n = 30) – a control group of women with normal hemoglobin levels during pregnancy and delivery.Results. The use of ferrous sulfate (Sorbifer durules) at a dose of 200 mg per day by pregnant women with IDA led to the fact that the weight-height parameters in newborns did not differ from those of children from healthy puerperas. At the same time, the volume of blood loss was greater in patients with IDA, however, there were no massive bleedings and moderate IDA in the postpartum period. The level of hemoglobin was significantly higher in women in labor who received ferrous sulfate (Sorbifer Durules) from the II trimester compared with pregnant women who had IDA in the III trimester. Thus, further research and the search for optimal dosages are required, as well as determining the most effective period for the use of iron supplements.Conclusions. Good tolerability and high efficacy of Sorbifer Durules in relation to a significant increase in hemoglobin and the absence of severe complications of pregnancy and childbirth associated with anemia allow us to recommend it for the treatment of IDA in pregnant women and puerperas.

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