To evaluate the effects of ovarian surgery on the deranged episodic gonadotrophln release of women wlth the poiycystic ovarlan disease (PCOD), we studled 11 patlents wlth the clitkal and endocrinoioglcai feature8 of PCOD before and after laparoscoplc laser coagulations of ovarian surfaces and cysts. Durlng both occasions), blood was collected at 1CmIn tntervals for 8 h to determlne LH and FSH secretory proflles and addltlonally for 3 h durlng GnRH lnjectlons (25 pg twlce within 2 h) to assess pltultary responslveness. Serum testosterone, androstendione and oestrogen (oestrone, oestradlol) levels were markedly reduced (P

The feasibility and efficacy of laparoscopic CO2 laser and Nd:YAG non-contact laser application for the treatment of polycystic ovarian disease (PCOD) were evaluated in 30 patients (19 patients treated with the CO2 laser, and 11 with the Nd:YAG laser). The criteria for inclusion of PCOD in our study were: amenorrhea or oligomenorrhea with chronic anovulation, failure to ovulate in response to clomide or human menopausal gonadotropin, elevated serum levels of luteinizing hormone (LH) or an elevated LH/follicle-stimulating hormone ratio, exaggerated LH response to gonadotrophin-releasing hormone (GnRH), elevated serum androgen levels, and ultrasonographic features of polycystic ovaries. Eight pregnancies after CO2 laser and three after Nd:YAG laser were achieved. Decline of serum androgen concentrations was noted in both groups, but was significantly higher in the Nd:YAG laser group (from 3.4 +/- 0.4 ng/ml to 2.2 +/- 0.2 ng/ml). Nine patients checked before and after laser treatment showed a decrease in the characteristically exaggerated pituitary response to exogenous GnRH injection. There were no consistent findings of the pattern in LH pulsatility studied in 5 patients after Nd:YAG laser treatment. Ovarian status was investigated in 11 patients by second-look laparoscopy or cesarian section. There were absolutely no adhesions after Nd:YAG laser coagulation. Filmy adhesions were seen in 3 patients in the CO2 laser group.

No abstract