The findings in the present study suggest that in-office digital impressions and subsequent computer-aided design/computer-aided manufacturing (CAD/CAM) fabrication of ceramic crowns could result in marginal and internal fit similar to that of hot-pressed all-ceramic crowns. SUMMARYThe present in vitro study concerns determination of the pre-cementation gap width of all-ceramic crowns made using an in-office digital-impression technique and subsequent computer-aided design/computer-aided manufacturing (CAD/CAM) production. Two chairside video camera systems were used: the Lava Oral scanner and Cadent's iTero scanner. Digital scans were made of a first molar typodont tooth that was suitably prepared for an all-ceramic crown. The digital impressions were sent via the Internet to commercial dental laboratories, where the crowns were made. Also, an impression of the typodont tooth was made, poured, and scanned in order to evaluate the pre-cementation gap of crowns produced from scanning stone dies. These methods and systems were evaluated by creating replicas of the intermediate space using an addition-cured silicone, and the gap widths were determined using a measuring microscope. Hot-pressed leucite-reinforced glassceramic crowns were selected as a reference. The mean value for the marginal measuring points of the control was 170 lm, and the values for all the evaluated crowns ranged from 107 to 128 lm. Corresponding figures for the internal measuring points were 141-210 lm and 115-237 lm, respectively. Based on the findings in the present study, an in-office digital-impression technique can be used to fabricate CAD/CAM ceramic single crowns with a marginal and internal accuracy that is on the same level as that of a conventional hot-pressed glass-ceramic crown. In the pre-

Purpose To investigate if patients receiving neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (MIBC) had an increased risk of thromboembolic events (TEE) and to evaluate when these events occur on a timeline starting from 6 months pre-cystectomy, during NAC-administration and 60 months post-cystectomy. Methods Two hundred and fifty five patients undergoing radical cystectomy during 2009–2014 at three Swedish cystectomy centers (Umeå, Linköping and Sundsvall) were in-detail reviewed retrospectively, using individual medical records. One hundred and twenty nine patients were ineligible for analysis. NAC patients (n = 67) were compared to NAC-naïve NAC-eligible patients (n = 59). The occurrence of TEE was divided into different periods pre-cystectomy and post-cystectomy. Statistical analyses included Chi-squared and logistical regression tests. Results Significant associations were found between receiving NAC and acquiring a TEE during NAC therapy pre-cystectomy. All but one pre-cystectomy event was venous and all but one of the patients received NAC. 31% (14/45) of TEEs occurred pre-cystectomy. The incidence of TEEs pre-cystectomy in NAC-naive NAC-eligible patients was only 10% (2/20), whereas the incidence of TEEs in NAC patients occurred pre-cystectomy in 48% (12/25) and 11/12 incidents were detected during NAC therapy—this including 7/11 (64%) incidents affecting veins in anatomical conjunction with the placement of central venous access for chemotherapy administration. Conclusions There is a significantly increased risk for TEE pre-cystectomy during chemotherapy administration in MIBC patients receiving NAC, compared to the risk in NAC-naïve NAC-eligible MIBC patients. In 64% of the pre-RC TEEs in NAC patients, there was a clinical connection to placement of central venous access.