Research attending to the role of religion and spirituality in enhancing sexuality in marriage is virtually absent. In response to this scarcity, this longitudinal study examined the sanctification of marital sexuality among newly married, heterosexual individuals (N = 67; married 4-18 months at Time 1). Greater sanctification of marital sexuality early in the marriage predicted more frequent sexual intercourse, sexual satisfaction, and marital satisfaction 1 year later for individual respondents, after controlling for initial levels of the dependent variable as well as age, frequencies of religious service attendance and prayer, and biblical conservatism. Greater sanctification continued to longitudinally predict greater sexual frequency and sexual satisfaction after also controlling for initial marital satisfaction. Participants with higher initial levels of sanctification of marital sexuality, relative to those with lower levels, experienced smaller declines in sexual satisfaction across 1 year. Findings add to empirical evidence that greater sanctification of close relationships facilitates relational well-being. (PsycINFO Database Record