Pre-acid fracturing is an effective technique to improve productivity of tight reservoirs. While acid injection can clean the formation and improve the fracturing performance by reducing the fracture pressure of the reservoir, the chemical reaction of the acid solution with proppant may reduce the compressive strength of the proppant and therefore negatively affect the fracture conductivity. In this study, we experimentally investigated the solubility of the proppant in acid and the effect of acid corrosion on proppant compressive strength and fracture conductivity. The results show that the concentration of the acid solution has the greatest effect on solubility of the proppant, which is followed by the contact reaction time. Though a proppant of larger particle size indicates a lower solubility, the acid corrosion poses a greater damage to its compressive strength and conductivity. The quartz sand proppant exhibits superior stability to ceramic proppant when they are subjected to acid corrosion. The experimental results could serve as reference for selection of proppant and optimization of acid concentration and duration of acid treatment during pre-acid fracturing.