No abstract

Keywords: Enantioselectivity / Oxo phosphonates / Michael addition / Organocatalysis / Asymmetric catalysis β-Oxo phosphonates have been proven to be alternative Michael donors in Michael addition reactions to nitro olefins in the presence of cinchonine-based bifunctional thiourea, affording a direct and atom-economic approach to the ef-

No abstract

N-thiophosphoryl Imines: Convenient Substrates in the Aza-Henry Reaction. -N-thiophosphoryl imines are used as substrates in aza-Henry reactions. Compared to N-diphenylphosphinoylimines, the thio analogue has the advantages of ease preparation and its stability to water, heat as well as silica gel. An asymmetric version is also realized and affords better enantioselectivities than the corresponding reaction with N-diphenylphosphinoylimine. -(HU, K.; WANG, C.; MA, X.; WANG*, Y.; ZHOU, Z.; TANG, C.;

Chiral Thiourea-Catalyzed Asymmetric Michael Addition of β-Oxo Phosphonate to Nitro Olefins: Convenient Synthesis of Optically Active β-Oxo Phosphonates. -In the presence of cinchonine-based bifunctional thiourea catalyst CTU, α-substituted β-oxo phosphonates are formed. The method is limited to aromatic nitro olefins. Steric effects are the key factor in the stereocontrol of the method, and with an increase in the steric hindrance of the olefin, the enantioselectivity increases also. -(HU, K.; LIU, T.; LU, A. D.; LIU, Y.; WANG*, Y.; WU, G.; ZHOU, Z.; TANG, C.; Eur.