Karst Rock desertification is one of the ecological geology problems in southwest of China. The investigation of this problem can provide scientific evidence for its evolution analysis and post arrangement, so monitoring the dynamic change of desertification using quick, precise and economic method is the most important task. In this paper, the fundamental remote sensing dynamic monitoring theory and method is applied, and it mainly discussed these aspects including remote sensing data choice, data preprocessing, extraction of rock desertification change information, classification of rock desertification information, etc. It summed up the technologic route and method of the Karst rock desertification monitoring using remote sensing technology. Based on the research of testing area and random sample investigation, it is indicated that the result using this method is precise and satisfying.