Background:The COVID-19 pandemic has made it necessity that rehabilitation services are provided remotely to patients. These process required a transformation in healthcare. The aim of this study was investigate the effectiveness of the home-based online supervised exercise program in Alzheimer's disease (AD). To our knowledge, this is the first study to report the results of real-time supervised physical exercise telerehabilitation program in AD.Method: Eighteen subjects with early-middle stage of AD were randomised into 2 group as telerehabilitation group (TG; mean age: 77.7 ± 5.29 years; 7 Female, 3 Male) and control group (CG; mean age: 78.5 ± 7.07 years; 5 Female, 3 Male). Our primary outcome was Mini-Mental State Examination (MMSE), seconder outcomes were Timed Up&Go (TUG), One-leg Balance Test (OLBT), Functional Independence Measure (FIM), Geriatric Depression Scale-Short Form (GDS). The 6-week motor-cognitive dual-task exercise training was performed online and under the supervision of physiotherapist through videoconference. No physical or cognitive intervention was applied to the control group for 6 weeks. Subjects were assessed before and after the treatment. In statistical analysis, the change in the outcome scores was calculated (∆ = last measurement-first measurement), the difference between the groups was performed with the Mann Whitney-U Test in SPSS 22.0. Trial's protocol is registered with Clinicaltrials.gov under number NCT04606251.Result: There was a significant difference between TG and CG in favor of TG in MMSE, TUG, FIM and GDS (p<0,05); There was no significant difference between groups in OLBT (p>0,05). Statistical results have been showed in Table 1. No safety problem was observed during the treatment. All subjects were completed the study, there was a high adherence to treatment. Conclusion: Physical exercise treatment with telerehabilitation was feasible, safe and well-accepted by people with early-middle stage of AD. Online-supervised exercise program can improve cognitive function, functional mobility, independence and reduce depressive symptoms.

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Background: Family caregiving in Alzheimer's Disease (AD) has been associated with a variety of negative psychological and social processes, including social isolation.Besides, it has been shown that the caregiver's physical activity level is one of the factors associated with the burden of care. The negative impact of physical inactivity on general health status is well established. This study aimed was investigate relationship between social support and caregiver's physical acitivity level.Methods: Participants' working-caregiving status and functional independency of their patients was recorded. Physical activity level was assessed with Rapid Physical Activity Assessment (RAPA). Percieved Social Support Questionnary (PSSQ) was used for evaluating of social support. Statistical analysis was performed by Spearman correlation analysis in SPSS 22.0 package program.Results: Among the 59 participants 88.4% were female and mean age was 54.83±11.9 years. Caregiver's demographics presented in Table 1. There was a significant correlation was found between RAPA and PPSQ (p = .015, rho = .321). According to RAPA results, 6.7% respondents were reported have no physical activity, 66.7% were underactive, and 13% were active. Conclusions:Our study was demonstrated that most of the caregivers were physically underactive. Supportive social environment was found related with caregivers physical activity level. It is necessary to be aware of the potential health risks not only for people with AD but also for caregivers. Caregivers should be encouraged to be physically active considering the positive effects on physical and mental health. Policy makers should develop strategies that support caregivers, taking into account all the components that are affect them physically, socially and psychologically.

Background Alzheimer’s disease (AD) not only effects the cognitive level, but also leads to significant decline in motor skill. Manual dexterity emerges with the interaction of cognitive and motor processes and is seen as an important predictor of functional independence. The aim of this study was to compare manual dexterity in people with AD with healthy older adults and to investigate the effect of cognitive level on manual dexterity. Method The Nine Hole Peg Test (NHPT) was used for manual dexterity assessment. Cognitive function were assessed with Montreal Cognitive Assessment (MoCA). Statistical analysis was performed by Mann Whitney U Test and regression analysis in SPSS 22.0 package program. Result Twenty nine people with AD (78.04±6.49, 48.27% female) and ten cognitively healthy older adult (74.8±7.22, 30% female) included study. NHPT results of the dominant hand were 31.87±7.33 sec. and 21.66±2.85 sec.; MoCA scores were 13.79±5.76 and 24.5±2.32, respectively, in the people with AD and cognitively healthy older adults. There was significant difference in NHPT results between groups (p<.001). Significant correlation was found between NHPT and MoCA (p<.001, r = .648). It was found that cognitive level significantly predicted manual dexterity (β = .648, R2 = .42, F [1,27] = 19.58, p<.001). Conclusion Manual dexterity in AD shows a significant decrease compared to the cognitively healthy older adults. In our study, it was shown that the decrease in manual dexterity occurs with the effect of cognition at a rate of 42%. Deteriorating manual dexterity with decreased cognition is likely to accelerate patients' withdrawal from activities of daily living. Also, rehabilitation programs that include activities for manual dexterity may slow down the process of participation restriction in AD.