Purpose: This cross-sectional study aims to explore the effect of pediatric nurses' perceptions and attitudes of coronavirus on their quality of life. Methods: It was carried out between the dates of June-August, 2021. The sample of the study consisted of 80 pediatric nurses working in the pediatric clinics of a university hospital. “Perceptions and Attitudes Evaluation Scale towards the COVID-19 Pandemic” and "WHOQOL-BREF-TR Scale" were used to collect data which were collected by online survey method. Results: It was determined that the mean score of the spiritual and social domains of the quality of life of the pediatric nurses was at a moderate level, while the mean scores of the physical and environmental domains were found to be below the medium level. According to the results of the regression analysis, the nurses' coronavirus perception and attitude sub-dimensions of dangerousness, macro, cognitive avoidance, common area avoidance and personal contact avoidance scores explained 30% of spiritual domain scores, and macro and common area avoidance sub-dimension scores explained 25% of social domain scores, macro and complo sub-dimensions scores explained 22% of environmental domain scores. Conlusion: As a result, it was determined that pediatric nurses' perceptions and attitudes towards coronavirus effect their quality of life. In order to increase the quality of life of pediatric nurses, attempts should be made to help nurses in the conditions of the COVID-19 pandemic and to provide necessary protection conditions to minimize the physical, spiritual, social, and environmental effects of the pandemic.