No abstract

One of the impending approaches in anticancer chemistry is focused on the design of new metal compounds increase cytotoxicity, unambiguously to cancer cells. In this framework, the extensive range of coordination numbers, geometries, redox states, thermodynamic, kinetic features and the inherent properties of cationic metal ion and ligand itself provides the medicinal chemist an ample spectrum of reactivity. The science of bioinorganic chemistry involving the synthesis and biological investigation of inorganic complexes is gaining impetus [1-6]. In this regard, Schiff bases and their metal complexes have been studied for their interesting and important properties such as their ability to bind reversibly to oxygen, catalytic property, amino group transfer, photochromicity and complex formation [7]. Schiff bases ligands coordinate with metal ions via azomethine nitrogen. They have been studied extensively because of increasing recognition of their role in biological system. Schiff bases act as superior chelating agents for transition and nontransition metal groups and exhibit remarkable biological activities [8]. Coordination of these compounds with metal ions, such as copper and nickel enhance their biological activities.