Bisphosphonates are increasingly being used to treat several skeletal disorders such as osteoporosis. Several studies have shown that localized bisphosphonates improve orthodontic anchorage. Adverse reactions of the drug can be further avoided through more targeted drug delivery of this drug. The use of gold nanoparticles in bone tissue regeneration has shown promising results. The combination of bisphosphonate and gold nanoparticles has been shown to produce more targeted action through systemic administration in osteoporosis. The Adverse Effects of the Gold nanoparticle such as toxicity can be reduced through green synthesis.  Cissus Quadrangularis is a green edible medicinal plant used in Ayurvedic preparations to treat osteoporosis, general inflammatory conditions, ulcers, menstrual disorders, hemorrhoids, and a variety of other ailments. The purpose of this study was to green synthesize Bisphosphonate conjugated gold nanoparticles with Cissus quadrangularis extract and test their antimicrobial and cytotoxic activity.  Green synthesis of Bisphosphonate conjμgated gold nanoparticles using cissus quadrangularis extract was achieved and is characterised using visual colour change, uv spectrophotometer, TEM analysis. Gold nanoparticles have good antibacterial activity against Streptococcus mutans (150 ug/ml – 17 mm zone of Inhibition) & Lactobacillus (150 ug/ml – 20 mm zone of Inhibition) and showed 20% lethality at 50 ul concentration.