Among human cancers, sebaceous carcinoma of the eyelid may be one of those showing most frequent mutation of the p53 gene, which may not be caused by exposure to UV. p21(WAF1/CIP1) downregulation may be associated with lymph node metastasis.

Purpose. To perform multivariate analysis for identifying independent predictors of elevated intraocular pressure (IOP) with neovascular glaucoma (NVG), including antivascular endothelial growth factor (VEGF) intravitreal injections. Methods. We retrospectively reviewed 142 NVG patients (181 eyes) with ischemic retinal diseases [proliferative diabetic retinopathy (PDR) in 134 eyes, retinal vein occlusion (RVO) in 29, and ocular ischemic syndrome in 18]. We analyzed age, gender, initial/final LogMAR VA, initial/final IOP, extent of iris and/or angle neovascularization, treatments, preexisting complications, concurrent medications, and follow-up duration. Results. The mean follow-up duration was 23.8 ± 18.8 months. At the final follow-up, 125 (72.3%) eyes had IOP ≤ 21 mmHg. NVG patients with RVO had a higher degree of angle closure and higher IOP. NVG with PDR had better IOP and LogMAR VA. Angle closure had the greatest impact on final IOP. Greater than 90% of patients treated with trabeculectomy with mitomycin C (LEC) had persistent declines in IOP (≤21 mmHg). Stand-alone and combination anti-VEGF therapies were not associated with improved long-term prognosis of IOP. Conclusions. Angle closure was found to have the greatest effect on NVG-IOP prognosis. When target IOP values are not obtained after adequate PRP with or without anti-VEGF, early LEC may improve the prognosis of IOP.

Objective: To present a method of indocyanine green angiography (IA) and fluorescein sodium angiography (FA) for simultaneously evaluating anterior segment neovascularization and fundus abnormality.Participants: We examined 19 eyes of 19 patients suspected of having neovascularization in the anterior segment of the eye. Seventeen eyes of 17 patients suffered from proliferative diabetic retinopathy, and two eyes of 2 patients had central retinal vein occlusion.Methods: Using Heidelberg Retina Angiograph 2 (HRA2), we performed angiography of the anterior and posterior segment of the eye.Results: Of the 19 cases, anterior segment neovascularization was clearly observed with slit-lamp examination and gonioscopy in 12 eyes (63.1%). However, anterior segment neovascularization was detected by HRA2 angiography in 18 eyes (94.7%). Posterior segment angiography revealed non-perfusion area in 16 eyes (84.2%) and retinal neovascularization in 10 eyes (52.6%). In one case, the posterior segment findings were not obtained due to vitreous hemorrhaging.Conclusion: Simultaneous anterior and posterior segment HRA2 angiography using indocyanine green andfluorescein sodium is a useful technique for detecting neovascularization in the anterior segment of the eye as well as non-perfusion areas and neovascularization of the retina.