Background: Chimaphila Umbellata plays a key role in treating urinary tract infections in adolescent girls. Various factors influence the urinary tract infections like intake of birth control medicines, excessive sexual activity, and lack of personal hygiene. The current single-blinded randomized study was designed to know the effectiveness of Chimaphila Umbellata in adolescent girls of the age group 13 to 25 years. It was found that out of 30 cases most of the cases were found among the 14 years of age group. After the intervention with Chimaphila Umbellata, the intensity of clinical manifestations like pain, burning, and itching was reduced. The VAS score was statically evaluated and then concluded that Chimaphila Umbellata has a tremendous effect in treating urinary tract infections in adolescent girls. Keywords: Urinary tract infection, Chimaphila Umbellata, adolescent girls, VAS scale, Homoeopathy, Single Blind RCT