Nowadays worldwide, an estimated 200 million people have chronic kidney disease (CKD). Diabetic nephropathy is a diagnosis that refers to specific pathologic structural and functional changes seen in kidney patients with Type 2 Diabetes Mellitus (T2DM). Incretins such as Glucagon like peptide 1(GLP-1) control blood glucose level through different metabolic pathways; for example, inhibition of glucagon production, and delay in gastric emptying and satiety induction. Accumulated evidence suggests that long term treatment with GLP-1 receptor agonist is associated with a reduction in measured glomerular filtration rate (GFR), preservation of renal function and/or a decrease in the incidence of cardiovascular events.