Hydrogen production via partial oxidation of methanol (POM) in an ultrasonic spray system was studied experimentally, using an h-BN-Pt/Al 2 O 3 catalyst with ultra-low Pt contents (0.2 wt%). The effects of oxygen-to-methanol (O 2 /C) ratio, methanol flow rate, and gas hourly space velocity (GHSV) of air and carrier gas on H 2 yield were examined. Compared to conventional spray systems, the ultrasonic spray system could produce more uniformly dispersed methanol and thus further enhance the POM reaction. The results showed a higher O 2 /C ratio (0.8) enhanced the POM, which poses higher CH 3 OH conversion, higher reaction temperature, and lower CO and CH 4 productions. The CO 2 concentration was mainly affected by GHSV and CH 3 OH flow rate. A higher GHSV led to a quicker retention time for the reactants in the catalyst bed, and a lower CH 3 OH flow rate deteriorates the CO 2 concentration. Based on the Box Behnken design (BBD) from response surface methodology (RSM) and analysis of variance (ANOVA), the optimal operating conditions are found to be O 2 /C ratio = 0.8, CH 3 OH flow rate = 0.7 mL min À1 , and GHSV = 10 000 h À1 . Combining these conditions, the predicted maximum H 2 yield is 1.635 mol‧(mol CH 3 OH) À1 which is close to the experimental value of 1.646 mol‧(mol CH 3 OH) À1 . The RSM and ANOVA not only resulted in a quadratic response surface regression model and significant regression coefficients but also indicated CH 3 OH flow rate being the primary factor.analysis of variance (ANOVA), h-BN-Pt/Al 2 O 3 catalyst, hydrogen production, partial oxidation of methanol (POM), response surface methodology (RSM), ultrasonic sprays