The incorporation of nanomaterials into a range of polymeric materials shows great potential for developing new active food packaging systems. Although there are many suggested benefits of nanoparticles (NPs) in food packaging, there are also potential risks due to the possibility of such particles migrating into foodstuffs. This has obvious implications for human health and it may also negatively impact on marketing and consumer confidence. This review focuses on 2 particular types of nanomaterials: nanoclays and nanosilver, with a view to examining the effects of these on system mechanical properties (nanoclays) and antimicrobial efficacy (nanosilver). It further reports on the various migration studies, techniques for characterization, and measurement of NPs as well as the potential migration of NPs from packaging into foodstuffs. Assessment of the literature to date suggests there is an urgent need for further research in order to devise better NP detection methods and to determine the likelihood of their migration from packaging materials into foodstuffs.