Summary Liver disease is a form of sickness that starts in the ovaries and is particularly dangerous for women. As a result, aberrant cells develop that have the potential to spread to other parts of the body. Liver disease is a sort of risky improvement that impacts ovaries in ladies, and is hard to perceive at early phase because of which it stays as one of the guideline wellsprings of illness end. Unquestionable confirmation of intrinsic and typical parts is immense in making novel frameworks to perceive and ruin danger. Here, using hybrid machine learning approaches, we propose an early detection and classification of liver disease (EDCLD) in ultrasound images. This study is aimed at detecting and evaluating liver disease, which may be benign or malignant depending on the cancer type. To begin with, we use an improved ant swarm optimization algorithm for both high and low level feature extraction models. For liver disease classification, we used hybrid swallow swarm intelligent‐deep neural network (HSSI‐DNN) classifier to identify the disease stage. By using training and testing liver datasets, we are improving the accuracy of liver disease detection with several stages. Second, we present a search optimization for whales algorithm for cascaded and segmentation as a single fusion feature capable of representing both the texture patterns and semantic background distributed in the image. Third, the dividend yields are commitment to the HSSI‐DNN classifier used to detect the “Normal” and “Diseases” from input image. The proposed HSSI‐DNN classifier performance outperformed the existing classifier in terms of accuracy (0.98), specificity (0.98), and sensitivity (1). The proposed EDCLD technique implemented in MATLAB.