Objective: The aim of the study was to examine the connection among BMI and chose visual boundaries like IOP. Methods: Three hundred stout subjects and 200 age- and sex-matched sound subjects were signed up for this planned cross-sectional review. Ophthalmological assessments including intraocular pressure (IOP) and refractive mistake were performed regarding each matter. Visual assessment included estimation of refractive mistake for far off vision with Snellen’s outlines or ignorant E diagram at 6 m in a sufficiently bright room Height and weight of all subjects were recorded and weight list (BMI) was determined. Results: It was observed that the IOP of the overweight gathering was fundamentally higher (13.56±3.12 mm Hg) than that of the typical weight bunch (11.86±2.12 mm Hg) p<0.01. Conclusion: It was observed that BMI firmly corresponded with expanded IOP. Likewise, the level of corpulence was viewed as a critical variable; in this way, the connection between these visual boundaries and the seriousness of stoutness ought to be additionally explored.

Introduction: In cancer chemotherapy platinum drugs do cause damage to the normal cells and as a result, many physiological functions are derailed. Renal function as measured by measured glomerular filtration rate (mGFR) plays a large role in drug dosing on the basis of the maximum tolerated dose, which is the highest dose that may be administered without unacceptable toxicity, to maximize anticancer efficacy.Objective: The objective of the study was to compare the toxic effect of platinum drugs on renal function as measured by mGFR in patients with malignancy and to study the difference in the magnitude of nephrotoxicity by these drugs.Methodology: The study was conducted in the Department of Physiology in close collaboration with the Department of Radiotherapy at a tertiary care centre in Western Rajasthan, India. 150 patients suffering from different malignances undergoing treatment with cisplatin, carboplatin, and oxaliplatin were examined for their renal function as measured by mGFR using 99m Tc-diethylene triamine pentaacetic acid ( 99m Tc-DTPA) and were compared with 50 subjects of control group.Results: In the cisplatin group there was a gradual fall of GFR from 85.49 ml/min/1.73sqm to 58.09ml/min/1.73sqm at cycle II. In the carboplatin group it was 84.86ml/min/1.73sqm at baseline whereas cycle II was 75.5 ml/min/1.73sqm with SD ± 16.49. mGFR fell significantly (p<0.0001) in cisplatin and carboplatin groups but not in the cohort of patients who received oxaliplatin. The GFR reduction continued from the baseline to cycle I and then cycle II in cisplatin and carboplatin groups.Conclusion: Nephrotoxicity is a major side effect of platin drugs and further studies should be done to establish their optimal dose in relation to renal function and minimize toxicity by trying various cytoprotective agents.

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