Cerebral Autosomal Dominant Arteriopathy with Sub-Cortical Infarcts and Leukoencephalopathy (CADASIL) is a rare autosomal genetic disorder that affects the brain’s small vessels. It is recognized among the leading causes of stroke in the young. This is a case report of a 35-year-old female with underlying migraine with auras who presented with recurrent cryptogenic strokes. She presented no vascular risk factors or any family history of neurological disease. An investigation into her presentation leads us to a diagnosis of CADASIL following typical subcortical and deep white matter changes seen on her Magnetic Resonance Imaging (MRI).

This is a case report of a 27-year-old male who presented with recurrent facial swelling and weakness. The clinical evaluation revealed that the patient had Melkersson-Rosenthal syndrome (MRS), a rare neurological disease characterized by the triad of recurrent facial edema, recurrent facial muscle weakness, and a furrowed or fissured tongue. Accurate data regarding the incidence of MRS is challenging to obtain due to the rarity of the disorder, and early recognition and treatment can potentially reduce the probability of permanent disability.