No abstract

LatarBelakang : Hiperurisemi dipengaruhi oleh keadaan dislipidemia dan asupan purin. Kondisi dislipidemia mengakibatkan menurunnya aktivitas enzim GA3PDH (Glyceraldehyde 3 phospate dehydrogenase) yang menyebabkan terjadinya diversi ribose-5-phospate menjadi PRPP (phosphoribosyl pyrophosphate). PRPP lalu ditransformasi menjadi inosine monophosphate (IMP). Dari senyawa perantara yang berasal dari adenosine monophosphate (AMP) dan guanosine monophosphate (GMP), purinic nucleotides digunakan untuk sintesis DNA dan RNA, dilanjutkan dengan  inosinyang kemudian akan mengalami degradasi menjadi hipoxantin, xantindan akhirnya menjadiasam urat. Asupan purin yang berlebihan seperti kacang tanah juga dapat meningkatkan kadar asam urat darah. Penelitianinibertujuanuntukmengetahuiperbedaan pengaruhasupan kacang tanah rebus dan panggang pada wanita dislipidemia.Metode : Jenis penelitian adalah true experiment dengan rancangan pre test – post test. Subjek adalah 22 wanita dislipidemia dengan kadar kolesterol LDL  ≥ 130 mg/dl,  HDL ≤ 40 mg/dl dan kadar asam urat normal 2,4-6,1 mg/dl. Subjek dibagi menjadi 2 kelompok dengan metode simple randomization, yang terdiri atas kelompok perlakuan pertama dan kelompok perlakuan kedua, masing-masing kelompok terdiri dari 11 subjek. Kelompok perlakuan pertama mendapatkan kacang tanah rebus sebanyak 77 gram/hari dan kelompok perlakuan kedua mendapatkan kacang tanah panggang sebanyak 77 gram/hari. Pemberian kacang tanah rebus dan panggang dilakukan selama 4 minggu. Uji normalitas menggunakan Shapiro Wilk. Analisis statistik menggunakan uji dependent t-test dan independent t-test.Hasil : Rerata kadar asam urat sebelum intervensi pada kelompok rebus yaitu 3,94 mg/dl dan pada kelompok panggang 4,45mg/dl. Rerata kadar asam urat  setelah intervensi pada kelompok rebus yaitu 4,79 mg/dl dan pada kelompok panggang 4,41mg/dl. Ada perubahan rerata kadar asam urat darah setelah diberikan kacang rebus (p=0,002). Tidak ada perubahan rerata kadar asam urat darah setelah diberikan kacang panggang (p=0,851).Kesimpulan : Ada perbedaan pengaruh konsumsi kacang tanah rebus dan panggang terhadap kadar asam urat darah pada wanita dislipidemia. Ada perubahan rerata kadar asam urat darah setelah diberikan kacang tanah rebus (p=0,002).

Abstract Blood glucose level could be measured before 2-3 months using glycated haemoglobin (HbA1c). In diabetes mellitus (DM) the size of low-density lipoprotein (LDL-K) often changes to a small size, called small dense LDL-K sdLDL) which is atherogenic and low high-density lipoprotein (HDL) level. High HbA1c indicates uncontrolled glucose levels and often cause complications of coronary heart disease (CHD). This is a further investigation from the previous one about ”The Relationship between HbA1c with LDL and Apo B in DM patients with cardiac complications." This study used analytical, cross-sectional design. Thirty patients DM with CHD complications were examined for HbA1C levels via the Exchange-HPLC ion methods, HDL-K and LDL-K by enzymatic colourimetric methods and apo B by the immunoturbidimetry methods. The relationship between variables was analyzed by the Pearson correlation test.The mean level of HbA1c was 8.72%, male HDL was 35.67 mg / dl, female was 39.57 mg / dl, LDL-K was 110.64 mg / dl, apo B was 111.88 mg / dl and sd-LDL was 1, 02. A strong negative relationship between HbA1c and HDL levels for both men and women with r = - 0.647; r = - 0.675 with significance level p = 0.017; p = 0.008. Whereas HbA1c with sd-LDL has a weak negative relationship, but not significant (r = -0.352; p = 0.057). Hence, lipid profile measurement can be considered to monitor risk of cardiovacular diseases, particularly in those with abnormal blood glucose metabolism. AbstrakPemantauan kadar gula 2-3 bulan sebelumnya dapat diukur menggunakan glycated hemoglobin (HbA1c). Pada diabetes melitus (DM) ukuran low density lipoprotein (LDL-K) sering berubah menjadi kecil, yang dinamakan small dence LDL-K (sd-LDL) yang bersifat aterogenik, dan kadar high density lipoprotein (HDL) sering rendah. HbA1c yang tinggi menandakan kadar glukosa tidak terkontrol dan sering menyebabkan salah satu komplikasi ke penyakit jantung koroner (PJK). Penelitian ini merupakan penelitian lanjutan dari penelitian berjudul “ Hubungan HbA1c dengan trigliserida dan Apo B pada penderita DM dengan komplikasi penyakit jantung” Studi ini menggunakan desain analitik potong lintang. Tiga puluh pasien DM dengan komplikasi PJK diperiksa kadar HbA1c melalui metoda ion-Exchange HPLC, HDL-K dan LDL-K dengan metoda kolometrik enzimatik dan apo B dengan metoda imunoturbidimetri. Hubungan antar variabel dianalisis dengan uji korelasi Pearson.Hasil penelitian didapatkan laki laki 16 dan perempuan 14 pasien. Kadar rerata HbA1c 8,72%, HDL laki laki 35,67 mg/dl, perempuan 39,57 mg/dl, LDL-K 110,64 mg/dl, apo B 111,88 mg/dl dan sd-LDL 1,02. Hubungan negatif kuat antara kadar HbA1c dan HDL baik laki laki maupun perempuan dengan r = - 0,647 ; r = - 0,675 dengan tingkat kemaknaan p = 0,017; p = 0,008. Sedangkan HbA1c dengan sd-LDL terdapat hubungan negatif lemah, tetapi tidak bermakna (r=-0,352 ; p = 0,057). Karena itu, pemeriksaan profil lipid dapat dipertimbangkan untuk memantau risiko penyakit kardiovaskular khususnya bagi mereka dengan gangguan metabolisme gula darah

Thalassemia major is one of the types of thalassemia that need a routine blood transfusion. If not treated immediately, the patient will only last for 1-8 months. Blood transfusions performed at least or more than 10 times causes iron overload. Excess levels of Fe ions in the body will be stored in the form of ferritin. If the ferritin level is high, cell damage will occur in the presence of a fat peroxidation reaction or Malondialdehyde (MDA). Cell damage can trigger proinflammation, which increases neutrophil counts and decreases lymphocyte counts. The Neutrophil-Lymphocyte Ratio (NLR), which measures the ratio between Absolute Neutrophil Count (ANC) divided by Absolute Lymphocyte Count (ALC) with a manual peripheral blood picture. This study aimed to determine the correlation of ferritin levels with MDA and NLR in iron overload. This study used an analytical observational design with a cross-sectional approach, with samples were thalassemia patients who received repeated blood transfusions at the General Hospital Dr. R Soetrasno, Rembang City and Regional General Hospital Dr. R Soedjati, Grobogan Purwodadi. Inclusion criteria were age 10-18 years, transfusion 10-20 times, normal body temperature. Exclusion criteria were Fe therapy orally, leukocytosis, chronic kidney disease. In the MDA levels, there was no significant difference where p=0.25 by Spearman test. In the NLR there was no significant difference where p=0.91 by Spearman test. There is no correlation between ferritin levels with MDA and NLR in iron overload.

Background: Cigarettes increase cardiovascular risks by modifying lipid profiles through oxidation, alternating lipoprotein composition, and fat metabolizing enzyme activity. Vascular dysfunction can primarily identified by LDL cholesterol composition shift, one of atherosclerosis predictor. Rosella is a multifunctional herb that widely used as a pleasant tea. Aside from its rich components, anthocyanin, pectin, PCA and hibiscus acid are playing the role keys in lowering LDL cholesterol through lipid metabolism enzyme activity modification. Rosella is easy to find, relatively cheap, tasteful and also categorized as food-grade FDA approved.Aim:  To investigate the effect of rosella infusion in decreasing LDL cholesterol serum on cigarettes exposed male Sprague dawley rat.Methods: This study is a true experimental study design with post-test only controlled group design. After 7 days of adaptation, a total of 30 male Sprague dawley rats were randomly divided into 5 groups (n=6 per group); KN received no special treatment; KP exposed to 4 rods of cigarette smoke/day; experimental groups (P1, P2, P3) exposed to 4 rods of cigarette smoke/day and rosella dried calyx infusion with 250, 500 and 1000 mg/kg respectively for 30 consecutive days. LDL cholesterol levels are measured using the CHOD-PAP method. Collected data were analyzed statistically using One Way ANOVA Test.Results: There is a significant difference between all experimental groups (p=0,00) in the post-hoc test.Conclusion: These lines of evidence suggest that rosella infusion significantly decreases LDL Cholesterol serum level in cigarettes exposed Sprague dawley rats in a dose-dependent manner.Keywords: Cigarettes smoke, LDL cholesterol, Rosella calyx infusion