Cardiovascular diseases are a global problem in the structure of healthcare around the world. This is due to their high prevalence and mortality. In their structure, the largest percentage is CHD, one of the manifestations of which is myocardial infarction. Another no less formidable pathology is type 2 diabetes mellitus. This disease is polyethological and is characterized by either insulin resistance or a reduced amount of insulin, or both at the same time. For this reason, it is necessary to develop new approaches to assessing the functional state of comorbid patients with myocardial infarction and diabetes mellitus, as well as determining the risk of mortality in patients with these pathologies. Thus, the aim of the study was to determine the relationship of indicators of oxidative stress with the risk of death of comorbid patients on the basis of a hospital. The article is relevant, since myocardial infarction and diabetes mellitus are formidable diseases, despite the fact that even in the era of the development of thrombolytic therapy, the mortality rate of patients with myocardial infarction and type 2 diabetes is still high. The material for the study was the examination of 59 patients diagnosed with myocardial infarction, verified by clinical and functional methods: 47 survivors and 12 people who died in hospital. The presence of diabetes mellitus in patients was confirmed by anamnestic data (conclusions of narrow specialists of endocrinologists). The prognosis during the study was justified for the survivors of patients with myocardial infarction in 100.0% of cases, for patients with myocardial infarction who died in hospital, in 97.7% of cases. The accuracy of forecast execution achieved by using these variables is 98.3%.