No abstract

Gallotannin (GT) is derived from plant poly phenol and is associated with biological actions in a wide range of cells. In this study, we evaluated the effect of GT on apoptosis and cyclooxygenase-2 (COX-2) expression and attempted to shed light on the mechanism of action in A549 human lung carcinoma cells. We found that GT dramatically induced apoptosis as demonstrated by expression of p53 and active caspase-3 via western blot analysis and fragmented DNA as detected by DNA fragmentation and DAPI staining. We also observed that GT significantly causes COX-2 expression in a dose-dependent manner determined by western blot analysis. Phosphorylation of Akt and p38 was considerably increased by GT in A549 human lung carcinoma cells. Inhibition of Akt and p38kinase with LY294002 or SB203580 suppressed GT-induced apoptosis and COX-2 expression. Furthermore, we have shown that prevention of COX-2 with NS398 or indomethacin does not any effects on apoptosis induced by GT. Taken together, our present results suggest that GT regulates apoptosis and COX-2 expression through Akt and p38kinase pathway in A549, human lung carcinoma cells.

-This paper proposes a new FDI(Fault Detection and Isolation) method, which is called EPSA(Extended Parity Space Approach). This method is particularly suitable for fault detection and isolation of the system with one faulty sensor or two faulty sensors. In the system with two faulty sensors, the fault detection and isolation probability may be decreased when two faults are occurred between the sensors related to the large fault direction angle. Nonetheless, the previously suggested FDI methods to treat the two-faults problem do not consider the effect of the large fault direction angle. In order to solve this problem, this paper analyzes the effect of the large fault direction angle and proposes how to increase the fault detection and isolation probability. For the increase the detection probability, this paper additionally considers the fault type that is not detected because of the cancellation of the fault biases by the large fault direction angle. Also for the increase the isolation probability, this paper suggests the additional isolation procedure in case of two-faults. EPSA helps that the user can know the exact fault situation. The proposed FDI method is verified through Monte Carlo simulation.

Diabetes is a chronic disease resulting from an absolute or relative shortage of insulin, and it is a disease that requires continuous management throughout the lifetime. Most past diabetes education programs used educational methods for training; however, only a small number of studies on individual education methods were conducted for diabetic patients. Along with individualized educational methods, various instructional methods for knowledge delivery and self-control have been attempted, and one of these is a one-on-one mentoring process. Through such a program, children can acquire knowledge and management of diabetes, and systematic management can be maintained through mentoring and use of diabetic resources. Also, shared cultural and life experiences between the mentor and the mentee can help the children overcome the identity crisis of adolescence to produce a suitable emotional experience. These positive effects can reduce the socio-economic costs associated with diabetes through improved management of problems that can arise in diabetics.

In this study, theoretical super screen vibration analysis has been carried out to predict the dynamic characteristics of interactive waste particles. The vibrating screen is modeled of three assemblies such as screen, wastes guide, and supported screen. Then materials (or particles) of different size is to be separated by using the eccentric vibrator and classifying tilt plates. In processing separation mechanism, much lighter construction wastes (wood, Styrofoam, etc) and heavier materials are separated by staying time delay in a super screen. The design results, separation screen were able to know that small and larger particles are conspicuous difference each motion character according to trajectory particles, and small particles raise the probability in classifying tilt plates.