PurposeEven though adipose tissue-derived stem cells (ADSCs) have been spotlighted as a possible alternative for liver transplantation in an experimental setting, the mechanism by which ADSCs improve liver dysfunction remains poorly characterized. The objective of this study was to evaluate the therapeutic ability of undifferentiated ADSCs, and find a few clues on how ADSCs alleviate liver damage by comparing the transplantation routes.MethodsIn vitro generated human ADSCs were checked for surface markers and stage-specific genes for characterization. Afterwards, they were transplanted into C57BL/6 mice with CCl4-induced liver injury. The transplantations were made via tail vein, portal vein, and direct liver parenchymal injection. At 1 and 3 post-transplantation days, serum biochemical parameters and/or liver specimens were evaluated.ResultsWe have shown here that ADSCs have the characteristics of mesenchymal stem cells, and belong to endodermal and/or early hepatic differentiation stage. After transplantation into the mice with acute liver failure, markers of liver injury, such as alanineaminotransferase, aspartateaminotransferase, as well as ammonia, decreased. Of these transplantation routes, transplantation via tail vein rendered the most prominent reduction in the biochemical parameters.ConclusionUndifferentiated ADSCs have the ability to improve hepatic function in mice with acute liver injury. Moreover, our transplantation route study supports the theory that ADSCs in systemic circulation can exert endocrine or paracrine effects to ameliorate the injured liver.

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알루미늄 압출재의 투과손실 실험 대상 알루미늄 본 논문에서 사용된 알루미늄 압출재 시편은 현재 운행중 인 고속철도차량의 바닥 프레임의 제원을 선정하였다. 사용Abstract The frame elements of modern high speed trains are typically fabricated with extruded aluminum panels. However, the sound transmission loss (STL) of extruded aluminum panels is less satisfactory than flat panels with the same surface density. This study proposes a method for prediction of the sound transmission loss of extruded aluminum panels using finite element analysis. The panel is modeled by finite element analysis, and the STL is calculated using a measure of Sommerfeld radiation at the specimen surface, boundary conditions, and the internal loss factor of the material. In order to verify the validity of the predicted value, intensity transmission loss was measured on the aluminum specimen according to ASTM E2249-02. The proposed method of analysis will be utilized to predict the sound insulation performance of extruded aluminum panels for railway vehicles in the design stage, and to establish measures for their improvement. (1) 알루미늄 압출재의 투과손실 예측

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