Variability in the staging of T1 melanoma among pathologists when using the AJCC seventh edition criteria is closely related to the detection of mitotic figures, with BT playing a less prominent role. Decreased variability is expected after implementation of the eighth edition.

Pandemic-driven economic changes are measurable in days and weeks rather than months and years, underscoring a need for more timely economic data to inform the public. We summarize newly available estimates of spending using card transaction data that are available on the Bureau of Economic Analysis website and analyze correlations between card data and official series. We find that card data perform well in measuring large changes in the economy around the pandemic, although the correlations are much lower during a period of stability prior to the pandemic. This pattern is likely attributable to a shift in the signal-to-noise ratio over these periods.

Most melanomas are driven by BRAF(V600E)-activating mutations, while nevi harboring the same mutations have growth arrest. Although decreased p16 expression has been associated with melanoma formation, in recent work, p15 represented a primary effector of oncogene-induced senescence in nevomelanocytes that was diminished in melanomas. This study determined whether decreased p15 levels represent a general biomarker for the transition from nevus to melanoma. We performed p15 and p16 IHC analyses on a random series of nevi and melanomas. Staining was evaluated and graded for percentage and intensity to determine the H score. For real-time quantitative RT-PCR analysis of p15, RNA was extracted from FFPE sections from 14 nevus and melanoma samples via macrodissection. A two-sided t-test was used to evaluate between-group differences in mean H scores and qDCt values. p15 Expression was significantly increased in melanocytic nevi compared with melanomas (mean H scores, 254.8 versus 132.3; P < 0.001). On p15 staining, the H score differential was greater than that with p16 staining [122.5 (P < 0.001) and 64.8 (P Z 0.055), respectively]. Real-time quantitative RT-PCR analysis revealed a lower mean qDCt value in melanomas, consistent with lower p15 expression (P Z 0.018). Together, these data support the hypothesis that decreased p15 expression is a robust biomarker for distinguishing nevus from melanoma. (Am J Pathol 2016, 186: 3094e3099; http:// dx

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Empirical models of regional adjustment often control for aggregate effects when estimating the impact of region‐specific shocks on local economies. It is, however, difficult to filter out the effects of aggregate shocks—such as oil shocks, uncertainty shocks, or national recessions—because the incidence of these shocks varies across space and time. We propose an improved econometric method to control for this form of spatiotemporal heterogeneity, thereby yielding more accurate estimation of the effects of local shocks on regional economies. Applying the method to US states, we find that labour demand shocks are mostly absorbed through changes in participation; the migration response to these shocks is limited; and recoveries are highly protracted