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The indole ring presents a good platform for synthesis because of its nucleophilic capacity at C3, to a lesser extent at C2, and also through the indole anion at N1. The development of new indoles with strategically placed methoxy groups at C4 and C6, or C5 and C7, provides even better platforms not only through increased general activation, but also through specific activation at C7 and C4 respectively. As a result of this multi-faceted activity, it is possible to generate a variety of additional rings fused to the indole platform. This rather general strategy of molecular augmentation leads to new types of indole structures, some of which bear resemblance to natural indole alkaloids. A selection of examples is presented.

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