No abstract

We report the case of a 25-year-old woman, transferred from a regional hospital, who was admitted on the 20th day of her illness without improvement. Intoxication, jaundice of sclera and skin, lack of appetite persisted. Her symptoms were associated with liver damage caused by a co-infection with herpes simplex virus and Epstein-Barr virus. The disease proceeded in a severe form with complications. But timely diagnosis of the disease and adequate therapy helped to save the patient’s life. риводится клинический случай 25-летней женщины, переведенной из областной больницы, которая поступила на 20-й день болезни без улучшения. Среди симптомов отмечалась интоксикация, желтушность склер и кожи, отсутствие аппетита. Ее симптомы были связаны с поражением печени, вызванным сопутствующей инфекцией — вирусом простого герпеса и вирусом Эпштейна-Барр. Заболевание протекало в тяжелой форме с осложнениями. Но своевременная диагностика заболевания и адекватная терапия помогли спасти жизнь пациентке.

Introduction. An analysis of two types of acute viral hepatitis (viral hepatitis B (HBV) and unverified hepatitis caused by the herpes simplex virus (HSV) is presented. A comparative description of the etiology and clinical and laboratory diagnostics is carried out. In both cases, the course of extremely severe forms with lethality was noted. Therefore, timely differential diagnosis is important in order to prescribe adequate antiviral therapy. The aim of the study was to observe a comparative clinical and laboratory characteristics of acute viral hepatitis B (HBV) and unverified hepatitis in persons infected with the herpes simplex virus (HSV). Materials and methods: under our supervision there were 65 patients with acute viral hepatitis hospitalized in the Republican Clinical Infectious Diseases Hospital (Bishkek) in the period 2018-2020. For comparative characteristics, the patients observed by us were divided into 2 groups: acute viral hepatitis B (45 patients) and unverified hepatitis (20 patients). The nosology, age, sex of patients was taken into account, the epidemiological history, clinical features and principles of treatment were carefully studied. Results and discussion. Observing the comparative clinical and laboratory characteristics of HBV and unverified hepatitis in persons infected with HSV, it was found that 90% of the observed patients are infected with HSV. Acute viral hepatitis B and unverified hepatitis in persons infected with HSV occurs in most cases in a moderate form. Fever with unverified hepatitis was observed in most cases (85%), which could be associated with the combined course of HSV. HSV infection can lead to severe adverse outcomes for both HBV and unverified hepatitis. Conclusions: Mandatory testing for HSV (ELISA, PCR) is required for all patients with HBV and unverified hepatitis. Timely administration of acyclovir against the background of generally accepted methods of treating acute viral hepatitis can lead to a favorable outcome of the disease.