Over past decades, physicians have recommended dietary adjustments, aimed at preventing or treating symptoms of peptic ulcer, as a diet that moderates the risk of stomach ulceration. This study aims to investigate the effect and mechanism of consumption of avocado (Persea americana Mill) juice and kiwi (Actinidia deliciosa) juice to alleviate peptic ulcer in rats. Thirty-six male albino rats (185±10 g), were used and divided into 6 equal groups, one was kept as a (-ve) control group, while the other groups were received daily oral dose of indomethacin (25mg / kg b.Wt.) once daily for 21 days. One group received Indo only (+ve control group), while the other groups given orally (1.5, 3 ml per day) of each juice for 21 days plus Indo. Peptic ulcer index, preventive index, and acidity of gastric juice were assessed. Nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) were measured in gastric tissue, as well as histopathological changes in the gastric mucosa. Treatment with avocado juice and kiwi juice resulted in amelioration of the gastric histological lesions induced by Indo. Moreover, fresh juices of avocado and kiwi significantly modulated biochemical marker of oxidative/nitrosative stress markers; malondialdehyde (MDA), and nitric oxide (NO) and antioxidant enzymes as glutathione (GSH), which were significantly disrupted in animal treated with Indo alone. According to this study, the fresh juices of avocado and kiwi could protect against peptic ulcer and its other side effects. This may be due to the high content of phenolic and flavonoid compounds in these juices.