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Directed ortho Metalation-Cross Coupling Connections. Remote Lateral Metalation-Cyclization of 2-Imino-2'-methyl Biaryl to 9-Aminophenanthrenes. A Synthesis of the Alkaloid Piperolactam C.-Various title compounds are synthesized from 2-imino-2'-methyl biaryls by a metalation-cyclization procedure. Aminophenanthrene (VIII) is converted to the alkaloid (X). -(BENESCH, L.; BURY, P.; GUILLANEUX, D.; HOULDSWORTH, S.; WANG, X.; SNIECKUS, V.; Tetrahedron Lett. 39 (1998) 9, 961-964; Dep. Chem., Univ. Waterloo, Waterloo, Ont. N2L 3G1, Can.; EN)

Synthesis and Bioactivity of β-Lactamase Inhibitory Iodopenicillanic Acid Derivatives.-The methyl esters of (II) and (III) are tested as β-lactamase inhibitors against a variety of isolated β-lactamases; they inhibit at various concentrations. The sulfoxide stereochemistry of the methyl ester of the (R)-oxide (III) is determined from 1 H and 13 C NMR data. -(PETRIKOVICS, I.; JASZBERENYI, J. C.; HERNADI, F.; SZTARICSKAI, F.; BOGNAR, R.; BATTA, G.; BENESCH, L.; Acta Chim. Hung. 128 (1991) 1, 41-51; Dep. Chemother., Univ. Med. Sch., H-4012 Debrecen, Hung.; EN)