The aim was to conduct a weighted single‐step genome‐wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein‐coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways (p‐value < .05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/Int‐1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste transduction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE‐related traits.

Brazil has the second largest commercial beef cattle herd in the world, occupying a prominent position in the global beef market. Zebu cattle (Bos indicus) comprise more than 80% of the beef cattle in Brazil, and the vast majority of these animals are from Nellore breed, given their tolerance to tropical climate and high resistance to ectoparasites (Baldi et al., 2012). Despite their advantages for production in tropical environments, Zebu cattle tend to produce tougher meat than Bos taurus breeds (Reverter et al., 2003;Thrift & Thrift, 2002). Brazilian beef quality tends to be highly variable, due to a broad diversity of production environments and management systems, and to a large proportion of Zebu animals in

RESUMO Existe a necessidade de intensificar a produtividade pecuária para alimentar a crescente população mundial. Sendo assim, objetivou-se avaliar a consorciação de pastagens Brachiaria com Estilosantes e Calopogônio sob aplicação de calagem e fosfatagem. Avaliou-se a produção de matéria orgânica e seca, densidade de perfilhos, teor de matéria seca e matéria mineral em pastagens degradadas de Brachiaria brizantha, com aplicação de calagem, fosfatagem e introdução de leguminosas. O delineamento experimental utilizado foi o inteiramente casualizado com parcelas subdividida, em que foram avaliados dois tipos de leguminosas (Estilosantes Campo Grande e Calopogônio) e três tipos de adubação (Controle, CaCo3, CaCo3 + P). A calagem e fosfatagem foram realizadas na superfície da pastagem sem incorporação. A introdução das leguminosas foi feita em plantio direto após superpastejo. As avaliações foram realizadas quando o dossel atingiu 25 cm de altura com auxílio de um quadrado de 0,25 m2. As leguminosas não diferiram para produção de matéria natural e seca das pastagens de Brachiaria brizantha (P>0,05), mas os fatores de correção e adubação (CaCo3 + P) melhoraram significativamente (P<0,05) a produção de massa das pastagens quando utilizou-se o Estilosantes Campo Grande em consorciação. Os resultados indicam a possibilidade de intensificar a produtividade pecuária usando leguminosas forrageiras, associadas com a fertilização CaCO3 + P, uma vez que são capazes de recuperar e aumentar a produtividade de pastagens cultivadas em regiões tropicais.

Context Livestock feed costs have a higher impact on the profitability of beef production systems and are directly related to feed efficiency. However, these traits are hard and have high costs to measure, reducing the availability of phenotypic records and reliability of genetic evaluations. Thus, the use of genomic information can increase the robustness of genetic studies that address them. Aims The aim of the present study was to estimate genetic parameters for feed efficiency, growth, reproductive and carcass traits in Nelore cattle and the correlated response among them, using genomic information. Methods Residual feed intake (RFI), dry-matter intake, feed conversion ratio, feed efficiency (FE), residual average daily gain (RG), residual feed intake and average daily gain (RIG), birthweight, weight at 120, 240, 365 and 450 days of age, scrotal circumference at 365 and 450 days of age, rib-eye area, backfat thickness and rump fat thickness were evaluated. The genetic parameters were estimated using the single-step genomic best linear unbiased prediction approach. Key results The FE-related traits showed low to moderate heritability ranging from 0.07 to 0.23. Feed efficiency-related traits showed low genetic correlations with reproductive (–0.24 to 0.27), carcass (–0.17 to 0.27) and growth (–0.19 to 0.24) traits, except for growth with dry-matter intake (0.32–0.56) and weight at 365 days of age with FE (–0.40). Conclusions The selection to improve growth, reproductive and carcass traits would not change RFI, RG and RIG. The choice of the most adequate selection criterion depends on the production system, that is, RFI might be used for low-input beef cattle systems, and RIG would be used for more intensive and without-any-dietary-restrictions beef cattle systems. Implications The estimates of heritability and genetic correlations suggest that genetic selection for feed efficiency using RFI, RG and RIG in Nellore cattle leads to higher genetic gain than does that using FE and feed conversion ratio without affecting other profitability traits.