concentrations were still on a linear trend upward at 96 h in all treated groups. Experiment 2 was similar to Exp. 1 and compared 1.5 versus 3 g of sulpiride injected in the thoracic area. Blood sampling was extended to 168 h. Prolactin patterns were the same as in Exp. 1, and concentrations were still elevated at 168 h (dose effect, P ¼ 0.11). The magnitude of the responses averaged 15 to 30 ng/mL at 96 h after injection in both experiments. These results indicate that Crisco shortening is as effective for the slow release of sulpiride as the proprietary mixture of oily substances used in the past.

No abstract